After leaving Leo flat-lining at the end of the Christmas episode, April must deal with the outcome of the surgery. Facing her new reality, she must also face her first day back at work after being gone for four months. In remission and determined to move on with her life, her return reveals a new, young and ambitious boss at the paper who is ready to shake things up. But April’s attempt to make a good impression may fall short when she botches her first assignment. Meanwhile with an ideal marrow donor still to be found, Sara realizes it’s time to reach out to the 'other woman,' Natalie’s mother. Brenna eagerly anticipates Greer’s return to school, but will she get the happy reunion she’s been waiting for?